In September 2016, we completed our initial
public offering and listed our common shares on the Nasdaq Global Market. In the initial public offering, we issued and sold 6,900,000
common shares, including 900,000 common shares sold to the underwriters pursuant to the underwriters’ over-allotment option.
While none of our existing shareholders sold common shares in the initial public offering, the percentage ownership held by certain
shareholders decreased as a result of the issuance of the common shares sold by us in the initial public offering.
In July 2018, we completed three offerings
of our common shares. In these offerings, we issued and sold 10,000,000 common shares, including 1,108,695 sold to the underwriters
pursuant to the underwriters’ over-allotment option. The percentage ownership held by certain shareholders decreased as a
result of the issuance of the common shares sold by us in these offerings.
|B.||Related party transactions
On July 31, 2018, as part of the Company’s
previously announced second subscription rights offering, a major shareholder and members of the Board and Executive Management
purchased an aggregate of 614,147 of the Company’s common shares on the same basis and otherwise on the same terms as the
other participants in such rights offering.
The above transaction represents the only
related party transactions we have entered into since January 1, 2018 with any of our executive officers, directors and holders
of more than 10% of any class of our voting securities, or any member of the immediate family of any of the foregoing persons,
other than the compensation arrangements we describe under “Item 6. Directors, Senior Management and Employees–B. Compensation.”
Registration Rights Agreement
We entered into a registration rights agreement
in connection with the Series E Private Placement with certain investors in the Series E Private Placement pursuant to which we
granted them certain demand and piggyback registration rights for the resale of the common shares held by them, as described below.
The registration rights described below will expire on the earlier to occur of (i) the fifth anniversary of the completion
of our initial public offering and (ii) the date on which there are no remaining registrable securities held by the parties
to the registration rights agreement. The registration rights agreement provides that we must pay certain registration expenses
in connection with any demand, piggyback or shelf registration. The registration rights agreement contains customary indemnification
and contribution provisions.
Demand Registration Rights
Pursuant to the terms of the registration
rights agreement, a shareholder or group of shareholders holding at least 10% of our outstanding common shares may request that
we effect a registration under the Securities Act of all or any portion of such requesting shareholders’ registrable securities.
As of March 1, 2019 dievini Hopp BioTech holding GmbH & Co KG and Varuma AG were our only shareholders party to the registration
rights agreement holding at least 10% of our outstanding commons shares, and together they beneficially held 30,040,099 of our
common shares, representing approximately 44.5% of the voting power of our common shares outstanding as of March 1, 2019. At least
10 business days prior to the anticipated filing date of the registration statement relating to such demand registration, we must
give all other shareholders party to the registration rights agreement notice of such requested registration. Within five business
days of such notice, any of the other shareholders party to the registration rights agreement may request that we also effect the
registration of the registrable securities held by them. We will not be required to effect a registration of all such registrable
securities unless the aggregate proceeds expected to be received from the sale of such registrable securities equals or exceeds
USD 10 million or such lesser amount that constitutes all of the requesting shareholders’ registrable securities (provided
that such lesser amount is at least USD 5 million). In no event will we be required to effect more than two demand registrations
or underwritten take downs referred to under “Shelf Registration Rights” below. Depending on certain conditions, we
may postpone a demand registration on two occasions during any period of twelve consecutive months for up to 90 days.
Piggyback Registration Rights
Pursuant to the terms of the registration
rights agreement, at any time after the trigger date, if we propose to register any of our securities, whether or not for sale
for our own account, we must give notice to the shareholders party to the registration rights agreement, and they will be entitled
to certain piggyback registration rights allowing them to add any of their remaining registrable securities in the registration,
subject to certain marketing and other limitations. As a result, whenever we propose to file a registration statement under the
Securities Act, the holders of these shares are entitled to notice of the registration and to request that we include their shares
in the registration.
Shelf Registration Rights