Opportunity for AC Immune
in Neurodegenerative Diseases
We intend to change the way that neurodegenerative
diseases are treated and to differentiate our business by combining reliable diagnostic tools that facilitate intervention at earlier
stages of the disease with therapies that treat the underlying disease, caused by misfolded protein targets. As shown in the diagram
below, AC Immune’s pipeline, comprised of antibodies, vaccines and small molecules, is well situated to address the present
and future treatment paradigms of neurodegenerative diseases involving different disease-modifying treatments at various points
in the progression of the disease, including combinations thereof.
Figure 6: Treatment and diagnosis of
Our therapeutic product candidates seek
to modify the course of AD by intervening at an earlier stage of the disease progression prior to irreversible neuronal damage.
Beyond AD, we believe that we can leverage our proprietary platforms to generate additional molecules that treat the causes of
other neurodegenerative and neuro-orphan diseases, such as Parkinson’s disease, multiple system atrophy, PSP, frontotemporal
dementia, Pick’s disease, Corticobasal degeneration and Huntington’s disease. We believe that the future treatment
paradigm for neurodegenerative diseases will involve different disease-modifying treatments used at various points in the progression
of the disease. One such combination may be passive immunization targeting Abeta together with anti-Tau antibodies or immunotherapies
and small molecules targeting Abeta or Tau.
We believe that we are a leader in discovering
new PET imaging agents to improve the timing and accuracy of diagnoses in neurodegenerative diseases. We have three diagnostic
candidates in our pipeline that were developed through our Morphomer platform that target Tau, alpha-synuclein and TDP-43. We believe
our Tau-PET imaging program has received external validation through our partnership with Life Molecular Imaging, a leader in imaging
agents. We are also developing an alpha-synuclein and TDP-43 PET imaging agent for PD and other neurodegenerative diseases. We
believe that our diagnostic product candidate pipeline will complement our disease-modifying treatment product candidate pipeline,
with the ultimate goal of reshaping the clinical course and treatment of neurodegenerative diseases.