AC Immune Reports Initiation of a Phase 2 Substudy to Increase Understanding of Disease Progression in Familial Alzheimer’s Disease
Prof.
The substudy will evaluate the effect of crenezumab, an anti-Abeta antibody, on the longitudinal Tau burden in a subgroup of presymptomatic Presenilin1 (PSEN1) E280A mutation carriers and non-carriers enrolled in API, a landmark study in
The API trial in
Participants in the new substudy will receive up to three intravenous injections of Genentech Tau Probe 1 and will undergo a Tau PET scan after each injection. The primary outcome measure will be change over time in Tau distribution, measured at week 130 up to week 260 of the main study.
“Treating earlier and testing in homogeneous populations are two important elements in AC Immune’s Roadmap to success and, both strategies are being applied in the API trial. Testing therapeutics in a homogeneous group in people carrying the PSEN1 E280A mutation earlier in the preclinical development phase, may make it possible to identify successful treatment strategies for treating this debilitating disease,” added Prof. Pfeifer.
It has been reported that many leaders in the field remain convinced that beta amyloid plays an important role in the initiation of AD. It is widely believed to be possible that studies to date have not intervened early enough or during the period before patients become symptomatic. As such, there may be an opportunity for early intervention with an investigational therapy such as crenezumab.
About Crenezumab
Crenezumab was discovered by
About
For further information, please contact:
US Investors Joshua Drumm, Ph.D. AC Immune Investor Relations Phone: +1 646 876 5538 E-mail: joshua.drumm@acimmune.com |
US Media Katie Gallagher or Sharon Correia LaVoieHealthScience Phone: +1 617 792 3937 E-mail: kgallagher@lavoiehealthscience.com scorreia@lavoiehealthscience.com |
European Media Judith Moore AC Immune Global Communication Lead Phone: +44 7932 053829 E-mail: judith.moore@acimmune.com |
European Investors & Media Chris Maggos LifeSci Advisors Phone: +41 79 367 6254 E-mail: chris@lifesciadvisors.com |
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Source: AC Immune SA