Crenezumab Phase II cognition data in Alzheimer's disease presented

Jul 16, 2014
  • Two phase II studies in people with mild-to-moderate Alzheimer's disease over 18 months and a total of 522 patients
  • The proof of concept ABBY study met overall objective of estimating treatment effects and demonstrated positive trends in cognitive endpoints over time, although the study did not meet its co-primary endpoints
  • Larger effects seen in patients with mild disease on high-dose of crenezumab intravenously
  • Acceptable risk benefit profile
  • Next steps to be determined by Roche following further analysis of data