United States securities and exchange commission logo

                          April 30, 2021

       Joerg Hornstein
       Chief Financial Officer
       AC Immune SA
       EPFL Innovation Park, Building B
       1015 Lausanne

                                                        Re: AC Immune SA
Statement on Form F-3
                                                            Filed April 28,
                                                            File No. 333-255576

       Dear Mr. Hornstein:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Kasey
Robinson at 202-551-5880 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Derek Dostal