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  <xsd:import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://fasb.org/srt/2022" schemaLocation="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/2020-01-21" schemaLocation="https://www.xbrl.org/dtr/type/2020-01-21/types.xsd" />
  <xsd:element name="ExpensesOperatingAbstract" id="aciu_ExpensesOperatingAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IssueOfEquityRestrictedShareAwards" id="aciu_IssueOfEquityRestrictedShareAwards" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="CashAdvancesForRentDeposit" id="aciu_CashAdvancesForRentDeposit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="ChangesInWorkingCapitalAbstract" id="aciu_ChangesInWorkingCapitalAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AdjustmentsForIncreaseDecreaseInAccruedExpenses" id="aciu_AdjustmentsForIncreaseDecreaseInAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="AdjustmentsForDepreciationExpenseRightOfUseAssets" id="aciu_AdjustmentsForDepreciationExpenseRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="SupplementalNonCashActivityAbstract" id="aciu_SupplementalNonCashActivityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PurchaseOfPropertyPlantAndEquipmentClassifiedAsNoncashInvestingActivities" id="aciu_PurchaseOfPropertyPlantAndEquipmentClassifiedAsNoncashInvestingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="LaboratoryEquipmentMember" id="aciu_LaboratoryEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PercentageIncreaseInPropertyPlantAndEquipment" id="aciu_PercentageIncreaseInPropertyPlantAndEquipment" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfContractualUndiscountedCashFlowsTableTextBlock" id="aciu_ScheduleOfContractualUndiscountedCashFlowsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfRightOfUseAssetsImpactOnStatementsTextBlock" id="aciu_DisclosureOfRightOfUseAssetsImpactOnStatementsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ImpactOnStatementsOfIncomeLossAndCashFlowsAbstract" id="aciu_ImpactOnStatementsOfIncomeLossAndCashFlowsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ContractualUndiscountedCashFlowsForLeaseLiabilitiesAbstract" id="aciu_ContractualUndiscountedCashFlowsForLeaseLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EscrowDepositAmount" id="aciu_EscrowDepositAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element name="RightOfUseLeasedAssetsAbstract" id="aciu_RightOfUseLeasedAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ExpenseRelatingToLeases" id="aciu_ExpenseRelatingToLeases" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="CollaborationAgreementOf2014JanssenPharmaceuticalsMember" id="aciu_CollaborationAgreementOf2014JanssenPharmaceuticalsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SkaneUniversityHospitalMember" id="aciu_SkaneUniversityHospitalMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="GrantRevenueMember" id="aciu_GrantRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="GrantsMichaelJFoxFoundationMember" id="aciu_GrantsMichaelJFoxFoundationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="GoingConcernAbstract" id="aciu_GoingConcernAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AntidilutiveSecuritiesAbstract" id="aciu_AntidilutiveSecuritiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DilutiveEffectOfRestrictedShareAwardsSubjectToFutureVesting" id="aciu_DilutiveEffectOfRestrictedShareAwardsSubjectToFutureVesting" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DilutiveEffectOfShareOptionsIssuedAndOutstanding" id="aciu_DilutiveEffectOfShareOptionsIssuedAndOutstanding" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DilutiveEffectOfShareOptionsAndConvertibleInstrumentsOnNumberOfOrdinaryShares" id="aciu_DilutiveEffectOfShareOptionsAndConvertibleInstrumentsOnNumberOfOrdinaryShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="GeneralInformationAbstract" id="aciu_GeneralInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfGeneralInformationAboutTheEntityExplanatoryTextBlock" id="aciu_DisclosureOfGeneralInformationAboutTheEntityExplanatoryTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TradeAndOtherPayablesAndAccruedLiabilitiesTable" id="aciu_TradeAndOtherPayablesAndAccruedLiabilitiesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TradeAndOtherPayablesAndAccruedLiabilitiesLineItems" id="aciu_TradeAndOtherPayablesAndAccruedLiabilitiesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DilutiveEffectOfConvertibleInstrumentsTextBlock" id="aciu_DilutiveEffectOfConvertibleInstrumentsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfPrepaidExpensesAndAccruedIncomeTextBlock" id="aciu_DisclosureOfPrepaidExpensesAndAccruedIncomeTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PrepaidExpensesAndAccruedIncomeDisclosureAbstract" id="aciu_PrepaidExpensesAndAccruedIncomeDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FairValueOfFinancialAssetsAndLiabilitiesPolicyTextBlock" id="aciu_FairValueOfFinancialAssetsAndLiabilitiesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfAccountingPolicyForChangesInAccountingPoliciesRecentlyAdoptedTextBlock" id="aciu_DisclosureOfAccountingPolicyForChangesInAccountingPoliciesRecentlyAdoptedTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DescriptionOfAccountingPolicyForAccountingJudgmentsAndEstimatesPolicyTextBlock" id="aciu_DescriptionOfAccountingPolicyForAccountingJudgmentsAndEstimatesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="InProcessResearchAndDevelopmentIPRDAssetMember" id="aciu_InProcessResearchAndDevelopmentIPRDAssetMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PaymentsProceedsFromPurchasesSalesOfShortTermFinancialAssetsClassifiedAsInvestingActivities" id="aciu_PaymentsProceedsFromPurchasesSalesOfShortTermFinancialAssetsClassifiedAsInvestingActivities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfBasisOfPreparationAndChangesToAccountingPoliciesTextBlock" id="aciu_DisclosureOfBasisOfPreparationAndChangesToAccountingPoliciesTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="BasisOfPreparationAndChangesToAccountingPoliciesAbstract" id="aciu_BasisOfPreparationAndChangesToAccountingPoliciesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AccruedExpensesAbstract" id="aciu_AccruedExpensesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TreasurySharesAbstract" id="aciu_TreasurySharesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScheduleOfAccruedExpensesTableTextBlock" id="aciu_ScheduleOfAccruedExpensesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="CurrentAccruedExpenses" id="aciu_CurrentAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="AlphaSynucleinPetImagingDiagnosticAgentMember" id="aciu_AlphaSynucleinPetImagingDiagnosticAgentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="FollowOnGrantFundingReceived" id="aciu_FollowOnGrantFundingReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="FollowOnGrantFundingReceivedTotalForJointArrangement" id="aciu_FollowOnGrantFundingReceivedTotalForJointArrangement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="PaymentsForPreviousAccruals" id="aciu_PaymentsForPreviousAccruals" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="PaymentsForPerformanceRelatedRemuneration" id="aciu_PaymentsForPerformanceRelatedRemuneration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="ProceedsFromSaleOfTreasurySharesInPublicOfferingsNetOfUnderwritingFeesAndTransactionCosts" id="aciu_ProceedsFromSaleOfTreasurySharesInPublicOfferingsNetOfUnderwritingFeesAndTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" abstract="false" nillable="true" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element name="AssetAcquisitionsAxis" id="aciu_AssetAcquisitionsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SignificantAssetAcquisitionsTotalDomain" id="aciu_SignificantAssetAcquisitionsTotalDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SignificantAssetAcquisitionsAxis" id="aciu_SignificantAssetAcquisitionsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AllSignificantAssetAcquisitionsDomain" id="aciu_AllSignificantAssetAcquisitionsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SaleOrIssueOfTreasurySharesNetOfUnderwritingFeesAndTransactionCosts" id="aciu_SaleOrIssueOfTreasurySharesNetOfUnderwritingFeesAndTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TransactionCostsAssociatedWithSaleOfTreasurySharesInPublicOfferingRecordedInAccruedExpenses" id="aciu_TransactionCostsAssociatedWithSaleOfTreasurySharesInPublicOfferingRecordedInAccruedExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="NumberOfTechnologyPlatforms" id="aciu_NumberOfTechnologyPlatforms" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="AdditionalGrantAwarded" id="aciu_AdditionalGrantAwarded" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ItAndLaboratoryEquipmentMember" id="aciu_ItAndLaboratoryEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfTreasurySharesSoldDuringPeriod" id="aciu_NumberOfTreasurySharesSoldDuringPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ScheduleOfCashAndCashEquivalentsAndShortTermFinancialAssetsTableTextBlock" id="aciu_ScheduleOfCashAndCashEquivalentsAndShortTermFinancialAssetsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ProceedsFromIssueOfOrdinarySharesNetOfTransactionCosts" id="aciu_ProceedsFromIssueOfOrdinarySharesNetOfTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PaymentsForShareIssueCostsAssociatedWithIssuanceOfSharesInRelationToAssetAcquisitions" id="aciu_PaymentsForShareIssueCostsAssociatedWithIssuanceOfSharesInRelationToAssetAcquisitions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisclosureOfCashAndCashEquivalentsAndShortTermDepositsNotClassifiedAsCashAndCashEquivalentsTableTextBlock" id="aciu_DisclosureOfCashAndCashEquivalentsAndShortTermDepositsNotClassifiedAsCashAndCashEquivalentsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
</xsd:schema>
